営業品目

DIOモデル(Diet-Induced Obesity) マウスの論文

使用飼料 D12450B, D12451, D12492
Updated: May 08, 2012

  1. Alfadda, Axssim, et al. Mice with deletion of the mitochondrial glycerol-3-phosphate dehydrogenase gene exhibit a thrifty phenotype: effect gender. Am. J. Physiol. Regul. Integr. Comp. Physiol. 287: R147-R156, 2004.
  2. Allan, Mark, Eisen, Eugene, & Pomp, Daniel. The M16 Mouse: An outbred Animal Model of Early Onset Polygenic Obesity and Diabesity. Obesity Research. 12: 1397-1407. 2004.
  3. Andrikopoulos, Sofianos, et al. Extended life span is associated with insulin resistance in a transgenic mouse model of insulinoma secreting human islet amyloid polypeptide. Am. J. Physiol. Endocrinol. Metab. 286: E418-E424. 2004.
  4. Anini, Younes & Brubaker, Patricia. Role of Leptin in the Regulation of Glucagon-Like Peptide-1 Secretion. Diabetes. 62: 252-269. 2003.
  5. Blüher, Susann, et al. Responsiveness to Peripherally Administered Melanocortins in Lean and Obese Mice. Diabetes. 53: 82-90. 2004.
  6. Bowen, Heather, Mitchell, Tiffany, Harris, Ruth. Method of leptin dosing, strain, and group housing influence leptin sensitivity in high-fat-fed weanling mice. Am. J. Of Regul. Integr. Comp. Physiol. 284: R87-R100. 2003
  7. Bråkenhielm, Ebba, et al. Angiogenesis Inhibitor, TNP-470, Prevents Diet-Induced and Genetic Obesity in Mice. Circ Res. 94:1-10.2004.
  8. Brommage, Robert. Validation and calibration of DEXA body composition in mice. Am. J. Physiol. Endocrinol Metab. 285:E454-E459. 2002
  9. Brunengraber, Daniel, et al. Influence of diet on the modeling of adipose tissue triglycerides during growth. Am. J. Physiol. Endocrinol Metab. 285:E917-E925. 2003.
  10. Bullen, John, et al. Short-term resistance to diet-induced obesity in A/J mice is not associated with regulation of hypothalamic neuropeptides. Am. J. Physiol. Endocrinol Metab. 287:E662-E670. 2004.
  11. Cha, Youn-Soo, et al. Acanthopanax senticosus Extract Prepared from Cultured Cells Decreases Adiposity and Obesity Indices in C57BL/6J Mice Fed a High Fat Diet. Journal of Medicinal Food. 4:422-429. 2004.
  12. Challis, B.G., et al. Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY3-36. PNAS. 101:4695-4700. 2004.
  13. Chen, Jerry, et al. Physiologic and Pharmacologic Factors Influencing Glyceroneogenic Contribution to Triacylglyceride-Glycerol, Measured By Mass Isotopomer Distribution Analysis. The American Society for Biochemistry and Molecular Biol,ogy. 2005.
  14. Cohen, Alex, et al. Caveolin-1-deficient mice show insulin resistance and defective insulin receptor protein expression in adipose tissue. Am. J. Physiol. Cell Physiol. 285:C222-C235. 2003.
  15. Combs, Terry P., et al. A Transgenic Mouse with a Deletion in the Collagenous Domain of Adiponectin and Improved Insulin Sensitivity. Endocrinology. 145:367-383. 2004.
  16. Conarello, Stacey, et al. Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance. PNAS. 100:6825-6830. 2003.
  17. Della-Fera, Mary, et al. Resistance to IP leptin-induced adipose apoptosis caused by high-fat diet in mice. Biochemical and Biophysical Research Communications. 303:1053-1057. 2003.
  18. Dhar, Madhu, et al. Mice Heterozygous for Atp 10c, a Putative Amphipath Represent a Novel Model of Obesity and Type 2 Diabetes. Journal of Nutrition. 134:799-805. 2004.
  19. El-Haschimi, Karim, et al. Insulin Resistance and Liposystrophy in Mice Lacking Ribosomal S6 Kinase 2. Diabetes. 52:1340-1346. 2003.
  20. El-Haschimi, Karim, et al. Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J. Clin. Invest. 105:1827-1832. 2000.
  21. Felipe, Francisco, et al. Modulation of Resistin Expression by Retinoic Acid and Vitamin A status. Diabetes. 53:882-889. 2004.
  22. Feipe, F., et al. Up-Regulation of muscle uncoupling protein 3 gene expression in mice following high fat iet, dietary vitamin A supplementation and acute retinoic acid-treatment. International Journal of Obesity. 27:60-69. 2003.
  23. Fewlass, Darius, et al. Obesity-related leptin regulates Alzheimer's Aß. FASEB. 18:1870-1878. 2004.
  24. Freedman, Bethany , et al. A Dominant Negative Peroxisome Proliferator-activated Receptor-? Knock-in Mouse Exhibits Features of the Metabolic Syndrome. The Journal of Biological Chemistry. 17:1718-1726. 2005.
  25. Fu, Jin, et al. Oleylethanolamide regulates feeding and body weight through activatio3n of the nuclear receptor PPAR-a. Nature. 425:90-93.2003.
  26. Gavrilova, Oksana, et al. Liver Peroxisome Proliferator-activated Receptor ? Contributes to Hepatic Steatosis, Triglyceride Clearance, and Regulation of Body Fat Mass. The Journal of Biological Chemistry. 278:34268-34276. 2003.
  27. Gerin, Isabelle, et al. LXRß is Required for Adipocyte Growth, Glucose Homeostasis and ß Cell Function. The American Society for Biochemistry and Molecular Biology, Inc. 2005.
  28. Guo, Kai-Ying, et al. Effects of obesity on the relationship of leptin mRNA expression and adipocyte size in anatomically distinct fat depots in mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 287:R112-R119. 2004.
  29. Haltiner, Andrea, et al. Leptin action is modified by an interaction between dietary fat content and ambient temperature. Am. J. Physiol. Regul. Integr. Comp. Physiol. 287:
  30. R1250-R1255. 2004.
  31. Haluzik, Martin, et al. PPAR-a deficiency does not alter insulin sensitivity in mice maintained on regular or high fat diet: the hyper insulinem,ic-euglycemic clamp studies. Endocrinology. 145:1662-16672004.
  32. Hambly, Catherine, et al. Mice With Low Metabolic Rates Are Not Susceptible to Weight Gain When Fed a High-Fat Diet. Obesity Research. 13:556-566.2005.
  33. Hancock, Arthur, et al. Antiobesity effects of A-331440, a novel non-imidazole histamine H3 receptor antagonist. European Journal of Pharmacology. 487:183-197. 2004.
  34. Hancock, A.A., et al. Antiobesity evaluation of histamine H3 receptor (H3R) antagonist analogs of A-331440 with improved safety and efficacy. Inflammation Research. 54:S27-S29. 2005.
  35. Hancock, A.A., et al. Histamine H3 antagonists in models of obesity. Inflammation Research. 53:S47-S48. 2004.
  36. Harris, Ruth, et al. Leptin Resistance in mice is determined by gender and duration of exposure to high-fat diet. Physiology & Behaviro. 78:543-555. 2003.
  37. Hennige, Anita, et al. Upregulation of insulin receptor substrate-2 in pancreatic ß cells prevents diabetes. J. Clin Invest. 112:1521-1532. 2003.
  38. Hildebrandt, Audrey, et al. Antiobesity effects of chronic cannabinoid CB1 receptor antagonist treatment in diet-induced obese mice. European Journal of Pharmacology. 462:125-132. 2003.
  39. Hildebrandt, Audrey, et al. Validation of a high-resolution X-ray computed tomography system to measure murine adipose tissue depot mass in situ and longitudinally. Journal of Pharmacological and Toxicological Methods. 47:99-106. 2002.
  40. Hileman, Stanley, et al. Characterization of Short Isoforms of the Leptin Receptor in Rat Cerebral Microvessels and of Brain Uptake of Leptin in Mouse Models of Obesity. Endocrinology. 143:775-783. 2002.
  41. Ho, Lap, et al. Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease. The FASEB Journal. 2004.
  42. Holder, J. Lloyd, et al. Sim 1 gene dosage modulates the homeostatic feeding response to increased dietary fat in mice. Am. J. Physiol Metab. 287:E105-E113. 2004.
  43. Ishii, Makoto, et al. Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity. PNAS. 100:10540-10545. 2003.
  44. Bolleddula, Jayaprakasam, et al., Amelioration of Obesity and Glucose Intolerance inHigh-Fat-Fed C57BL/6 Mice by Anthocyanins and Ursolic Acid in Cornelian Cherry ( Cornus mas). J. Agric. Food Chem. 54:243-248. 2006.
  45. Jerez-Timaure, Nancy , et al. Characterization of QTL with Major Effects on Fatness and Growth on Mouse Chromosome 2. Obesity Research. 12:1408-1420. 204.
  46. Jiang, Tao, et al., Diet Induced Obesity In C57bl/6j Mice Causes Increased Renal Lipid Accumulation And Glomerulosclerosis Via A Sterol Regulatory Element Binding Protein-1c Dependent Pathway. The American Society for Biochemistry. 2005.
  47. Jiang, Guoqlang, et al. Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase. The Journal of Clinical Investigation. 2005.
  48. Joseph, Jaime, et al. Uncoupling Protein 2 Knockout Mice Have Enhanced Insulin Secretory Capacity After a High-Fat Diet. Diabetes. 51:3211-3219. 2002.
  49. Kim, S., et al. Effects of High-Fat Diet, Angiotensinogen (agt) Gene Inactivation, and Targeted Expression to Adipose Tissue on Lipid Metabolism and Renal Gene Expression. Horm. Metab. Res. 34:721-725. 2002.
  50. Kishino, Eriko, et al. A Mixture of the Salacia reticulate (Kotala himbutu) Aqueous Extract and Cyclodextrin Reduces the Accumulation of Visceral Fat Mass in Mice and Rats with High-Fat Diet-Induced Obesity. Journal of Nutrition. 136:433-439. 2006.
  51. Klover, Peter, et al. Interleukin-6 Depletion Selectively Improves Hepatic Insulin Action in Obesity. Endocrinology. 146:3417-3427. 2005.
  52. Kokkotou, Efi, et al. Mice with MCH ablation resist diet induced obesity through strain specific mechanisms. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2004.
  53. Kowalski, T., et al. Transgenic overexpression of neuromedin U promotes leanness and hypophagia in mice. Journal of Endocrinology. 185:151-164. 2005.
  54. Kumar, Monica, et al. Differential effects of a centrally acting fatty acid synthase inhibitor in lean and obese mice. PNAS. 99:1921-1925.2002.
  55. Lambert, P.D., et al. Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin resistant obesity. PNAS. 98:4652-4657. 2001.
  56. LeLay, Soazig, et al. Decreased Resistin to Mice with Different Sensitivities to High-Fat Diet. Biochemical and Biophysical Communications. 289:564-567. 2001.
  57. Lee, Jennifer, et al. Circulating resistin in lean, obese, and insulin-resistant mouse models: lack of association with insulinemia and glycemia. AJP-Endo. 288:625-632. 2005.
  58. Li, Jinping, et al. Insig-1 “brakes” lipogenesis in sdipocytes and inhibits differentiation of preadipocytes. PNAS. 100:9476-9481. 2003.
  59. Liang, Y. et al. Topiramate ameliorates hyperglycemia and improves glucose-stimulated insulin release in ZDF rats and db/db mice. Diabetes, Obesity, and Metabolism. 2004.
  60. Longo, Kenneth, et al. Wnt10b Inhibits Development of White and Brown Adipose Tissues. The Journal of Biological Chemistry. 279:35503-35509. 2004.
  61. Looije, Norbert, et al. Disodium Ascorbyl Phytostanyl Phosphates (FM-VP4) reduces plasma cholesterol concentration, body weight and abdominal fat gain within a dietary-induced obese mouse model. J. Pharm. Pharmaceut. Sci. 3:400-408.2005.
  62. Ludwig, David, et al. Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance. Journal of Clinincal Investigation. 107:379-386. 2001.
  63. Luo, Jiangming, et al. Reduced Fat Mass in Mice Lacking Orphan Nuclear Receptor Estrogen-Related Receptor a. Mollecular and Cellular Biology. 23:7947-7956. 2003.
  64. Masaki, Megumi, et al. Role of Meltrin a (ADAM12) in Obesity Induced by High-Fat Diet. 146:1752-1763. 2005.
  65. Masuzaki, Hiroaki, et al. A Transgenic Model of Visceral Obesity and the Metabolic Syndrome. Science. 294:2166-2170.2001.
  66. Moon, Yang Soo, et al. Mice Lacking Paternally Expressed Pref-1/Dlk1 Display Growth Retardation and Accelerated Adiposity. Molecular and Cellular Biology. 22:5585-5592. 2002.
  67. Mu, Huiling & Hoy, Carl-Erik. The digestion of dietary triacylglycerols. Progress in Lipid Research. 43:105-133. 2004.
  68. Murray, Ian, et al. Acylation Stimulating Protein (ASP) Deficiency Alters Postprandial and Adipose Tissue Metabolism in Male Mice. The Journal of Biological Chemistry. 274:36219-36225. 1999.
  69. Nonogaki, Katsunori, et al. Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2c receptor gene. Nature Medicine. 4:1152-1156. 1998.
  70. Patsouris, David, et al. Peroxisome Proliferator-Activated Receptor a Mediates the Effects of High-Fat Diet on Hepatic Gene Expression. Endocrinology. 147:1508-1516. 2006.
  71. Phan, Loan, et al. The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein. The Journal of Clinical Investigation. 110:1449-1459. 2002.
  72. Pierroz, Dominique, et al. Effects of Acute and Chronic Administration of the Melanocortin Agonist MTII in Mice With Diet-Induced Obesity. Diabetes. 51:1337-1345. 2002.
  73. Ragolia, Louis, et al. Accelerated Glucose Intolerance, Nephropathy, and Athersclerosis in Prostaglandin D2 Synthase Knockout Mice. The American Society for Biochemistry and Molecular Biology, Inc. 2005.
  74. Rahmouni, Kamal, et al. Role of Selective Leptin Resistance in Diet-Induced Obesity Hypertension. Diabetes. 54:2012-2018. 2005.
  75. Rajala, Michael, et al. Regulation of Resistin Expression and Circulating Levels in Obesity, Diabetes, and Fasting. Diabetes. 53:1671-1679. 2004.
  76. Rangwala, Shamina, et al. Genetic Modulation of PPAR? Phosphorylation Regulates Insulin Sensitivity. 5:657-663. 2003.
  77. Razani, Babak, et al. Caveolin-1-deficient Mice Are Lean, Resistant to Diet-Induced Obesity, and Show Hypertriglyceridemia with Adipocyte Abnormalities. The Journal of Biological Chemistry. 277:8635-8647. 2002.
  78. Rieusset, Jennifer, et al. A New Selective Peroxisome Proliferator-Activated Receptor ? Antagonist with Antiobesity and Antidiabetic Activity. Molecular Endocrinology. 16:2628-2644. 2002.
  79. Rosenfeld, Cheryl & Roberst, Michael. Maternal Diet and Other Factors Affecting Offspring Sex Ratio: A Review. 71:1063-1070. 2004.
  80. Rosenfeld, Cheryl, et al. Striking variation in the sex ratio of pups born to mice according to whether maternal diet is high in fat or carbohydrate. PNAS. 100:4628-4632. 2003.
  81. Roy, Suheeta, et al. A Biphasic Response of Hepatobiliary Cholesterol Metabolism to Dietary Fat at the onset of Obesity in the Mouse. Hepatology. 41:887-895. 2005.
  82. Scheuner, Donalyn, et al. Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis. Nature Medicine. 11:757-764. 2005.
  83. Scroocchi, Louise & Drucker, Daniel. Effects of Aging and a High Fat Diet on Body Weight and Glucose Tolerance in Glucagon-Like Peptide-1 Receptor -/- Mice. Endocrinology. 139. 3127-3132. 1998.
  84. Sleeman, Mar, et al. Absence of the lipid phodphatase SHIP2 confers resistance to dietary obesity. Nature Medicine. 2005.
  85. Souers, Andre J., et al. Synthesis and evaluation of urea-based indazoles as melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity. Bioorganic & Medicinal Chemistry Letters. 15:2752-2757. 2005.
  86. Sparks , Lauren, A high-Fat Diet Coordinately Downregulates Genes Required for Mitochondrial Oxidative Phosphorylation in Skeletal Muscle. Diabetes. 54:1926-1933.2005.
  87. Chirala, Subrahmanyam, et al. Fatty acid synthesis is essential in embryonic development: Fatty acid synthase null mutants and most of the heterozygotes die in utero. PNAS. 100:6358-6363. 2003.
  88. Tabarin, Antoine, et al. Resistance to Diet-Induced Obesity in µ-Opiod Receptor-Deficient Mice. 54:3510-3516. 2005.
  89. Takahashi, N., et al. Divergent Effects of Leptin in Mice Susceptible or Resistant to Obesity. Horm Metab Res. 34:691-697.2002.
  90. Tanaka, Tomohiro, Skeletal Muscle AMP-Activated Protein Kinase Phosphorylation Parallels Metabolic Phenotype in Leptin Transgenic Mice Under Dietary Modification. Diabetes. 54:2365-2374. 2005.
  91. Tang, Haiying, et al. High-resolution magnetic resonance imaging tracks changes in organ and tissue mass in obese and aging rats. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 282:R890-R899. 2002.
  92. Thupari, Jagan, et al. C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. PNAS. 99:9498-9502. 2002.
  93. Thupari, Jagan, et al. Chronic C75 treatment of diet-induced obese mice increases fat oxidation and reduces food intake to reduce adipose mass. Am. J. Physiol. Endocrinol. Metab. 287:E97-E104. 2004.
  94. Toney, Jeffrey, et al. A “Mix and Read” Assay for Insulin Using Fluorometric Microvolume Assay Technology. ASSAY and Drug Development Technologies. 1:521-525.2003.
  95. Tortoriello, Drew, et al. Dietary-Induced Obesity and Hypothalmic Infertility in Female DBA/2J Mice. Endocrinology. 145:1238-1247. 2004.
  96. Tritos, Nicholas, et al. Estradiol-Induced Anorexia Is Independent of Leptin and Melanin Concentrating Hormone. Obesity Research. 12:716-724.2004.
  97. Tu, Yojun, et al. C75 Alteres Central and Peripheral Gene Expression to Reduce Food Intake and Increase Energy Expenditure. Endocrinology. 146:486-493. 2005.
  98. Valet, Philippe, et al. Expression of Human a2-Adrenergic Receptors in Adipose Tissue of ß3-Adrenergic Receptor-deficient Mice Promotes Diet-induced Obesity. The Journal of Biological Chemistry. 275:34797-34802. 2000.
  99. Van Heek, Margaret, et al. Diet-induced Obese Mice develop Peripheral, but Not Central, Resistance to Leptin. J. Clin. Invest. 99:385-390. 1997.
  100. Vidal-Puig, et al. Energy Metabolism is Uncoupling Protein 3 Gene Knockout Mice. The Journal of Biological Chemistry. 275:16258-16266. 2000.
  101. Villena, Josep, et al. Induced Adiposity and Adipocyte Hypertrophy in Mice Lacking the AMP-Activated Protein Kinase-a2 Subunit. Diabetes. 53:2242-2249. 2004.
  102. Wang, Wei, et al. GDF-3 is an adipogenic cytokine under high fat dietary condition. Biochemical and Biophysical Research Communications. 321:1024-1031. 2004.
  103. Wei, P., et al. Glomerular structural and functional changes in a high-fat diet mouse model of early-stage Type 2 diabetes. Diabetologia. 47:1541-1549. 2004.
  104. Weisberg, Stuart, et al. Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 112:1796-1808.2003.
  105. Weisberg, Stuart, et al. CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J. Clin. Invest. 116:115-124. 2006.
  106. Werner, Eric, et al. Insulin Resistance Due to Phosphorylation of Insulin Receptor Substrate-1 at Serine 302. The Journal of Biological Chemistry. 279:35298-35305. 2004.
  107. Xu, Haiyan, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Invest. 112:1821-1830. 2003.
  108. 108.Yamashita, Tadashi, et al. Enhanced insulin sensitivity in mice lacking ganglioside GM3. PNAS. 6: 3445-3449. 2003.
  109. Yang, Jinzeng & Zhao, Baoping. Postnatal Expression of Myostatin PropMolecular Reproduction and Development. 73:462-469. 2006.
  110. Yu, Ying, et al. Role of PYK2 in the development of obesity and insulin resistance. Biochemical and Biophysical Research Communications. 334:1085-1091. 2005.
  111. Yu, Xing Xian, et al. Antisense Oligonucleotide Reduction of DGAT2 Expression Improves Hepatic Steatosis and Hyperlipidemia in Obese Mice. Hepatology. 42:362-371. 2005.
  112. Zhao, Baoping, et al. Transgenic expression of myostatin propeptide prevents diet-induced obesity and insulin resistance. Biochemical and Biophysical Research Comunications. 337:248-255. 2005.
  113. Ziotopoulou, Mary, et al. Differential expression of hypothalamic neuropeptides in the early phase of diet-induced obesity. Am. J. Physiol. Endocrinol. Metab. 279:E838-E845. 2000.
  114. Banerjee, Ronadip, et al. Regulation of Fasted Blood Glucose by Resistin. Science. 303:1195-1198.2004.
  115. Araki K, Masaki T, Katsuragi I, Tanaka K, Kakuma T, Yoshimatsu H. Telmisartan prevents obesity and increases the expression of uncoupling protein 1 in diet-induced obese mice. Hypertension. 2006;48:51-7.
  116. Costford SR, Chaudhry SN, Salkhordeh M, Harper ME. Effects of the presence, absence, and overexpression of uncoupling protein-3 on adiposity and fuel metabolism in congenic mice. Am J Physiol Endocrinol Metab. 2006; 290:E1304-12.
  117. Du X, Edelstein D, Obici S, Higham N, Zou MH, Brownlee M. Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation. J Clin Invest. 2006; 116:1071-80.
  118. Ito M, Suzuki J, Sasaki M, Watanabe K, Tsujioka S, Takahashi Y, Gomori A, Hirose H, Ishihara A, Iwaasa H, Kanatani A: Development of nonalcoholic steatohepatitis model through combination of high-fat diet and tetracycline with morbid obesity in mice. Hepatology Research. 2007;34:92-8.
  119. Kobayashi M, Ikegami H, Fujisawa T, Nojima K, Kawabata Y, Noso S, Babaya N, Itoi-Babaya M, Yamaji K, Hiromine Y, Shibata M, Ogihara T: Prevention and treatment of obesity, insulin resistance, and diabetes by bile acid-binding resin. Diabetes. 2007;56:239-47.
  120. Lumeng CN, Bodzin JL, Saltiel AR. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest. 2007;117:175-84.
  121. Lumeng CN, DeYoung SM, Bodzin JL, Saltiel AR: Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes. 2007;56:16-23.
  122. Mandard S, Zandbergen F, van Straten E, Wahli W, Kuipers F, Muller M, Kersten S. The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity. J Biol Chem. 2006; 281:934-44.
  123. Millward CA, Heaney JD, Sinasac DS, Chu EC, Bederman IR, Gilge DA, Previs SF, Croniger CM. Mice with a deletion in the gene for CCAAT/enhancer-binding protein beta are protected against diet-induced obesity. Diabetes. 2007;56:161-7.
  124. Patsouris D, Reddy JK, Muller M, Kersten S. Peroxisome proliferator-activated receptor alpha mediates the effects of high-fat diet on hepatic gene expression. Endocrinology. 2006;147:1508-16.
  125. Phan LK, Chung WK, Leibel RL. The mahoganoid mutation (Mgrn1md) improves insulin sensitivity in mice with mutations in the melanocortin signaling pathway independently of effects on adiposity. Am J Physiol Endocrinol Metab. 2006;291:E611-20.
  126. Qu S, Altomonte J, Perdomo G, He J, Fan Y, Kamagate A, Meseck M, Dong HH. Aberrant Forkhead box O1 function is associated with impaired hepatic metabolism. Endocrinology. 2006;147:5641-52.
  127. Ro HS, Zhang L, Majdalawieh A, Kim SW, Wu X, Lyons PJ, Webber C, Ma H, Reidy SP, Boudreau A, Miller JR, Mitchell P, McLeod RS. Adipocyte enhancer-binding protein 1 modulates adiposity and energy homeostasis. Obesity. 2007;15:288-302.
  128. Rodrigue-Way A, Demers A, Ong H, Tremblay A: A growth hormone-releasing peptide promotes mitochondrial biogenesis and a fat burning-like phenotype through scavenger receptor CD36 in white adipocytes. Endocrinology. 2007;148:1009-18.
  129. Sheng G, Chang GQ, Lin JY, Yu ZX, Fang ZH, Rong J, Lipton SA, Li SH, Tong G, Leibowitz SF, Li XJ. Hypothalamic huntingtin-associated protein 1 as a mediator of feeding behavior. Nat Med. 2006;12:526-33.
  130. Wolfgang MJ, Kurama T, Dai Y, Suwa A, Asaumi M, Matsumoto S, Cha SH, Shimokawa T, Lane MD. The brain-specific carnitine palmitoyltransferase-1c regulates energy homeostasis. Proc Natl Acad Sci. U S A. 2006;103:7282-7.
  131. Xu AW, Ste-Marie L, Kaelin CB, Barsh GS. Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding. Endocrinology. 2007;148:72-80.
  132. Yang JY, Lee SJ, Park HW, Cha YS. Effect of genistein with carnitine administration on lipid parameters and obesity in C57Bl/6J mice fed a high-fat diet. J Med Food. 2006;9:459-67.
  133. Yi X, Maeda N. alpha-Lipoic acid prevents the increase in atherosclerosis induced by diabetes in apolipoprotein E-deficient mice fed high-fat/low-cholesterol diet. Diabetes. 2006;55:2238-44.
  134. Yu R, Kim CS, Kwon BS, Kawada T. Mesenteric adipose tissue-derived monocyte chemoattractant protein-1 plays a crucial role in adipose tissue macrophage migration and activation in obese mice. Obesity. 2006;14:1353-62.
  135. Zhao Z, Lange DJ, Voustianiouk A, MacGrogan D, Ho L, Suh J, Humala N,
  136. Thiyagarajan M, Wang J, Pasinetti GM. A ketogenic diet as a potential novel therapeutic intervention in amyotrophic lateral sclerosis. BMC Neurosci. 2006;7:29.
  137. Zorilla, EP, et al. Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency. PNAS. 2007, 104:26:11097–11102.
  138. Koonen,D PY, et al. Increased Hepatic CD36 Expression Contributes to Dyslipidemia Associated With Diet-Induced Obesity. Diabetes. 2007, 56:2863- 2871.
  139. Lin, C, Mei-chin Yin. Effects of cysteine-containing compounds on biosynthesis of triacylglycerol and cholesterol and anti-oxidative protection in liver from mice consuming a high-fat diet. British Journal of Nutrition.2008, 99, 37–43.
  140. Anderson SR, Gilge DA, Steiber AL, Previs SF. Diet-induced obesity alters protein synthesis: tissue-specific effects in fasted versus fed mice. Metabolism. 2008 Mar;57(3):347-54.
  141. Bartels ED, Bang CA, Nielsen LB. Early atherosclerosis and vascular inflammation in mice with diet-induced type 2 diabetes. Eur J Clin Invest. 2009 Mar;39(3):190-9.
  142. Bederman IR, Previs SF. Hormonal regulation of intracellular lipolysis in C57BL/6J mice: effect of diet-induced adiposity and data normalization. Metabolism. 2008 Oct;57(10):1405-13.
  143. Bradley RL, Jeon JY, Liu FF, Maratos-Flier E. Voluntary exercise improves insulin sensitivity and adipose tissue inflammation in diet-induced obese mice. Am J Physiol Endocrinol Metab. 2008 Sep;295(3):E586-94. Epub 2008 Jun 24.
  144. Chadt A, Leicht K, Deshmukh A, Jiang LQ, Scherneck S, Bernhardt U, Dreja T, Vogel H, Schmolz K, Kluge R, Zierath JR, Hultschig C, Hoeben RC, Schürmann A, Joost HG, Al-Hasani H. Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity. Nat Genet. 2008 Nov;40(11):1354-9. Epub 2008 Oct 19.
  145. Crouthamel MC, Kahana JA, Korenchuk S, Zhang SY, Sundaresan G, Eberwein DJ, Brown KK, Kumar R. Mechanism and management of AKT inhibitor-induced hyperglycemia. Clin Cancer Res. 2009 Jan 1;15(1):217-25.
  146. Ebato C, Uchida T, Arakawa M, Komatsu M, Ueno T, Komiya K, Azuma K, Hirose T, Tanaka K, Kominami E, Kawamori R, Fujitani Y, Watada H. Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet. Cell Metab. 2008 Oct;8(4):325-32.
  147. Fang CX, Dong F, Thomas DP, Ma H, He L, Ren J. Hypertrophic cardiomyopathy in high-fat diet-induced obesity: role of suppression of forkhead transcription factor and atrophy gene transcription. Am J Physiol Heart Circ Physiol. 2008 Sep;295(3):H1206-H1215. Epub 2008 Jul 18.
  148. Feige JN, Lagouge M, Canto C, Strehle A, Houten SM, Milne JC, Lambert PD, Mataki C, Elliott PJ, Auwerx J. Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metab. 2008 Nov;8(5):347-58.
  149. Féral CC, Neels JG, Kummer C, Slepak M, Olefsky JM, Ginsberg MH. Blockade of alpha4 integrin signaling ameliorates the metabolic consequences of high-fat diet-induced obesity. Diabetes. 2008 Jul;57(7):1842-51. Epub 2008 Apr 21.
  150. Fukuchi Y, Hiramitsu M, Okada M, Hayashi S, Nabeno Y, Osawa T, Naito M. Lemon Polyphenols Suppress Diet-induced Obesity by Up-Regulation of mRNA Levels of the Enzymes Involved in beta-Oxidation in Mouse White Adipose Tissue. J Clin Biochem Nutr. 2008 Nov;43(3):201-9. Epub 2008 Oct 31.
  151. Gong Z, Huang C, Sheng X, Zhang Y, Li Q, Wang MW, Peng L, Zang YQ. The role of tanshinone IIA in the treatment of obesity through peroxisome proliferator-activated receptor gamma antagonism. Endocrinology. 2009 Jan;150(1):104-13. Epub 2008 Sep 25.
  152. Hong J, Smith RR, Harvey AE, Núñez NP. Alcohol consumption promotes insulin sensitivity without affecting body fat levels. Int J Obes (Lond). 2009 Feb;33(2):197-203. Epub 2009 Jan 6.
  153. Hong J, Stubbins RE, Smith RR, Harvey AE, Núñez NP. Differential susceptibility to obesity between male, female and ovariectomized female mice. Nutr J. 2009 Feb 17;8:11.
  154. Ikehara O, Kawasaki N, Maezono K, Komatsu M, Konishi A. Acute and chronic treatment of L-isoleucine ameliorates glucose metabolism in glucose-intolerant and diabetic mice. Biol Pharm Bull. 2008 Mar;31(3):469-72.
  155. Ito M, Gomori A, Suzuki J, Tsujioka S, Sasaki M, Matsuda M, Bednarek MA, Ito M, Ishihara A, Iwaasa H, Macneil DJ, Kanatani A. Antagonism of central melanin-concentrating hormone 1 receptor alleviates steatohepatitis in mice. J Endocrinol. 2008 Aug;198(2):309-15. Epub 2008 Jun 3.
  156. Kanda T, Brown JD, Orasanu G, Vogel S, Gonzalez FJ, Sartoretto J, Michel T, Plutzky J. PPARgamma in the endothelium regulates metabolic responses to high-fat diet in mice. J Clin Invest. 2009 Jan;119(1):110-24. doi: 10.1172/JCI36233. Epub 2008 Dec 8.
  157. Kiefer FW, Zeyda M, Todoric J, Huber J, Geyeregger R, Weichhart T, Aszmann O, Ludvik B, Silberhumer GR, Prager G, Stulnig TM. Osteopontin expression in human and murine obesity: extensive local up-regulation in adipose tissue but minimal systemic alterations. Endocrinology. 2008 Mar;149(3):1350-7. Epub 2007 Nov 29.
  158. Kim SJ, Nian C, Doudet DJ, McIntosh CH. Inhibition of dipeptidyl peptidase IV with sitagliptin (MK0431) prolongs islet graft survival in streptozotocin-induced diabetic mice. Diabetes. 2008 May;57(5):1331-9. Epub 2008 Feb 25.
  159. La Merrill M, Baston DS, Denison MS, Birnbaum LS, Pomp D, Threadgill DW. Mouse breast cancer model-dependent changes in metabolic syndrome-associated phenotypes caused by maternal dioxin exposure and dietary fat. Am J Physiol Endocrinol Metab. 2009 Jan;296(1):E203-10. Epub 2008 Oct 7.
  160. Lee J, Chae K, Ha J, Park BY, Lee HS, Jeong S, Kim MY, Yoon M. Regulation of obesity and lipid disorders by herbal extracts from Morus alba, Melissa officinalis, and Artemisia capillaris in high-fat diet-induced obese mice. J Ethnopharmacol. 2008 Jan 17;115(2):263-70. Epub 2007 Oct 5.
  161. Morgan DA, Thedens DR, Weiss R, Rahmouni K. Mechanisms mediating renal sympathetic activation to leptin in obesity. Am J Physiol Regul Integr Comp Physiol. 2008 Dec;295(6):R1730-6. Epub 2008 Sep 24.
  162. Ozcan L, Ergin AS, Lu A, Chung J, Sarkar S, Nie D, Myers MG Jr, Ozcan U.Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance. Cell Metab. 2009 Jan 7;9(1):35-51.
  163. Prior RL, Wu X, Gu L, Hager TJ, Hager A, Howard LR. Whole berries versus berry anthocyanins: interactions with dietary fat levels in the C57BL/6J mouse model of obesity. J Agric Food Chem. 2008 Feb 13;56(3):647-53. Epub 2008 Jan 23.
  164. Qatanani M, Szwergold NR, Greaves DR, Ahima RS, Lazar MA. Macrophage-derived human resistin exacerbates adipose tissue inflammation and insulin resistance in mice. J Clin Invest. 2009 Feb 2. pii: 37273. doi: 10.1172/JCI37273.
  165. Quinn LS, Anderson BG, Strait-Bodey L, Stroud AM, Argilés JM. Oversecretion of interleukin-15 from skeletal muscle reduces adiposity. Am J Physiol Endocrinol Metab. 2009 Jan;296(1):E191-202. Epub 2008 Nov 11.
  166. Roy C, Paglialunga S, Fisette A, Schrauwen P, Moonen-Kornips E, St-Onge J, Hesselink MK, Richard D, Joanisse DR, Cianflone K. Shift in metabolic fuel in acylation-stimulating protein-deficient mice following a high-fat diet. Am J Physiol Endocrinol Metab. 2008 Jun;294(6):E1051-9. Epub 2008 Apr 8.
  167. Shi H, Strader AD, Sorrell JE, Chambers JB, Woods SC, Seeley RJ. Sexually different actions of leptin in proopiomelanocortin neurons to regulate glucose homeostasis. Am J Physiol Endocrinol Metab. 2008 Mar;294(3):E630-9. Epub 2008 Jan 2.
  168. Shimizu H, Oh-I S, Hashimoto K, Nakata M, Yamamoto S, Yoshida N, Eguchi H, Kato I, Inoue K, Satoh T, Okada S, Yamada M, Yada T, Mori M. Peripheral administration of nesfatin-1 reduces food intake in mice: the leptin-independent mechanism. Endocrinology. 2009 Feb;150(2):662-71. Epub 2008 Oct 16.
  169. Singh R, Wang Y, Xiang Y, Tanaka KE, Gaarde WA, Czaja MJ. Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance. Hepatology. 2009 Jan;49(1):87-96.
  170. Takanabe R, Ono K, Abe Y, Takaya T, Horie T, Wada H, Kita T, Satoh N, Shimatsu A, Hasegawa K. Up-regulated expression of microRNA-143 in association with obesity in adipose tissue of mice fed high-fat diet. Biochem Biophys Res Commun. 2008 Nov 28;376(4):728-32. Epub 2008 Sep 20.
  171. Teegarden SL, Bale TL. Effects of stress on dietary preference and intake are dependent on access and stress sensitivity. Physiol Behav. 2008 Mar 18;93(4-5):713-23. Epub 2007 Nov 28.
  172. Thornton SJ, Wong E, Lee SD, Wasan KM. Effect of dietary fat on hepatic liver X receptor expression in P-glycoprotein deficient mice: implications for cholesterol metabolism. Lipids Health Dis. 2008 Jun 11;7:21.
  173. Trevaskis JL, Meyer EA, Galgani JE, Butler AA. Counterintuitive effects of double-heterozygous null melanocortin-4 receptor and leptin genes on diet-induced obesity and insulin resistance in C57BL/6J mice. Endocrinology. 2008 Jan;149(1):174-84. Epub 2007 Oct 11.
  174. Tsuneki H, Murata S, Anzawa Y, Soeda Y, Tokai E, Wada T, Kimura I, Yanagisawa M, Sakurai T, Sasaoka T. Age-related insulin resistance in hypothalamus and peripheral tissues of orexin knockout mice. Diabetologia. 2008 Apr;51(4):657-67. Epub 2008 Feb 7.
  175. Villena JA, Choi CS, Wang Y, Kim S, Hwang YJ, Kim YB, Cline G, Shulman GI, Sul HS. Resistance to high-fat diet-induced obesity but exacerbated insulin resistance in mice overexpressing preadipocyte factor-1 (Pref-1): a new model of partial lipodystrophy. Diabetes. 2008 Dec;57(12):3258-66. Epub 2008 Oct 3.
  176. Yu XX, Pandey SK, Booten SL, Murray SF, Monia BP, Bhanot S. Reduced adiposity and improved insulin sensitivity in obese mice with antisense suppression of 4E-BP2 expression. Am J Physiol Endocrinol Metab. 2008 Mar;294(3):E530-9. Epub 2008 Jan 15.
  177. Zhang W, Chai B, Li JY, Wang H, Mulholland MW. Effect of des-acyl ghrelin on adiposity and glucose metabolism. Endocrinology. 2008 Sep;149(9):4710-6. Epub 2008 Jun 5.
  178. Zuberi AR, Townsend L, Patterson L, Zheng H, Berthoud HR. Increased adiposity on normal diet, but decreased susceptibility to diet-induced obesity in mu-opioid receptor-deficient mice. Eur J Pharmacol. 2008 May 6;585(1):14-23. Epub 2008 Feb 26.

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